{"id":116,"date":"2026-06-03T08:10:17","date_gmt":"2026-06-02T23:10:17","guid":{"rendered":"https:\/\/hanachan.org\/?p=116"},"modified":"2026-06-03T10:30:38","modified_gmt":"2026-06-03T01:30:38","slug":"glp1-diet-rebound","status":"publish","type":"post","link":"https:\/\/hanachan.org\/?p=116","title":{"rendered":"\u30de\u30f3\u30b8\u30e3\u30ed\u30c0\u30a4\u30a8\u30c3\u30c8\u306f\u672c\u5f53\u306b\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u306e\uff1f\uff08\u30de\u30f3\u30b8\u30e3\u30ed\u30fb\u30ea\u30d9\u30eb\u30b5\u30b9\u30fb\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\u7b49GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u95a2\u3059\u308b\u8003\u5bdf\uff09"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/hanachan.org\/?p=116\/#TLDR\" >TL;DR<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/hanachan.org\/?p=116\/#1_%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB%EF%BC%9A%E3%80%8C%E3%83%AA%E3%83%90%E3%82%A6%E3%83%B3%E3%83%89%E3%81%97%E3%82%84%E3%81%99%E3%81%84%E3%80%8D%E3%81%A8%E3%81%84%E3%81%86%E8%A8%80%E8%91%89%E3%81%A0%E3%81%91%E3%81%A7%E5%88%A4%E6%96%AD%E3%81%97%E3%81%AA%E3%81%84%E3%81%9F%E3%82%81%E3%81%AB\" >1. \u306f\u3058\u3081\u306b\uff1a\u300c\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d\u3068\u3044\u3046\u8a00\u8449\u3060\u3051\u3067\u5224\u65ad\u3057\u306a\u3044\u305f\u3081\u306b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/hanachan.org\/?p=116\/#2_BMJ%E7%A0%94%E7%A9%B6%E3%81%8C%E7%A4%BA%E3%81%97%E3%81%9F%E3%81%93%E3%81%A8%EF%BC%9A%E8%96%AC%E3%82%92%E3%82%84%E3%82%81%E3%82%8B%E3%81%A8%E4%BD%93%E9%87%8D%E3%81%AF%E6%88%BB%E3%82%8A%E3%82%84%E3%81%99%E3%81%84\" >2. BMJ\u7814\u7a76\u304c\u793a\u3057\u305f\u3053\u3068\uff1a\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u306f\u623b\u308a\u3084\u3059\u3044<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-2\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/hanachan.org\/?p=116\/#3_%E3%81%9F%E3%81%A0%E3%81%97%E3%80%81%E8%96%AC%E3%81%AE%E6%96%B9%E3%81%8C%E3%81%9D%E3%82%82%E3%81%9D%E3%82%82%E5%A4%A7%E3%81%8D%E3%81%8F%E7%97%A9%E3%81%9B%E3%82%84%E3%81%99%E3%81%84\" >3. \u305f\u3060\u3057\u3001\u85ac\u306e\u65b9\u304c\u305d\u3082\u305d\u3082\u5927\u304d\u304f\u75e9\u305b\u3084\u3059\u3044<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/hanachan.org\/?p=116\/#%E5%8F%82%E8%80%83%E6%83%85%E5%A0%B1\" >\u53c2\u8003\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/hanachan.org\/?p=116\/#4_%E3%80%8C%E4%BD%95kg%E6%88%BB%E3%81%A3%E3%81%9F%E3%81%8B%E3%80%8D%E3%81%A0%E3%81%91%E3%81%A7%E3%81%AF%E8%A6%8B%E3%81%88%E3%81%AA%E3%81%84%E3%81%93%E3%81%A8\" >4. \u300c\u4f55kg\u623b\u3063\u305f\u304b\u300d\u3060\u3051\u3067\u306f\u898b\u3048\u306a\u3044\u3053\u3068<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/hanachan.org\/?p=116\/#5_%E3%80%8C%E6%88%BB%E3%82%8A%E5%B9%85_%C3%B7_%E7%97%A9%E3%81%9B%E5%B9%85%E3%80%8D%E3%81%A7%E8%A6%8B%E3%81%A6%E3%82%82%E3%80%81%E3%81%BE%E3%81%A0%E5%8D%81%E5%88%86%E3%81%A8%E3%81%AF%E8%A8%80%E3%81%88%E3%81%AA%E3%81%84\" >5. \u300c\u623b\u308a\u5e45 \u00f7 \u75e9\u305b\u5e45\u300d\u3067\u898b\u3066\u3082\u3001\u307e\u3060\u5341\u5206\u3068\u306f\u8a00\u3048\u306a\u3044<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/hanachan.org\/?p=116\/#6_%E6%9C%AC%E5%BD%93%E3%81%AB%E8%A6%8B%E3%81%9F%E3%81%84%E3%81%AE%E3%81%AF%E3%80%81BMI%E3%81%AE%E6%B5%81%E3%82%8C\" >6. \u672c\u5f53\u306b\u898b\u305f\u3044\u306e\u306f\u3001BMI\u306e\u6d41\u308c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/hanachan.org\/?p=116\/#7_BMJ%E7%A0%94%E7%A9%B6%E3%81%AE%E9%99%90%E7%95%8C%EF%BC%9ABMI%E3%81%AE%E6%B5%81%E3%82%8C%E3%82%92%E4%B8%AD%E5%BF%83%E3%81%AB%E8%A6%8B%E3%81%9F%E7%A0%94%E7%A9%B6%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84\" >7. BMJ\u7814\u7a76\u306e\u9650\u754c\uff1aBMI\u306e\u6d41\u308c\u3092\u4e2d\u5fc3\u306b\u898b\u305f\u7814\u7a76\u3067\u306f\u306a\u3044<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-3\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/hanachan.org\/?p=116\/#8_%E3%82%BB%E3%83%9E%E3%82%B0%E3%83%AB%E3%83%81%E3%83%89%E4%B8%AD%E6%AD%A2%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%EF%BC%9ASTEP_1%E5%BB%B6%E9%95%B7%E8%A9%A6%E9%A8%93\" >8. \u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u4e2d\u6b62\u5f8c\u306e\u7814\u7a76\uff1aSTEP 1\u5ef6\u9577\u8a66\u9a13<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-4\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/hanachan.org\/?p=116\/#9_%E3%83%81%E3%83%AB%E3%82%BC%E3%83%91%E3%83%81%E3%83%89%E4%B8%AD%E6%AD%A2%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%EF%BC%9ASURMOUNT-4\" >9. \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u4e2d\u6b62\u5f8c\u306e\u7814\u7a76\uff1aSURMOUNT-4<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-5\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/hanachan.org\/?p=116\/#10_SURMOUNT-4%E3%81%AE%E4%BA%8B%E5%BE%8C%E8%A7%A3%E6%9E%90%EF%BC%9A%E6%88%BB%E3%82%8A%E5%B9%85%E3%81%A8%E5%BF%83%E8%A1%80%E7%AE%A1%E4%BB%A3%E8%AC%9D%E6%8C%87%E6%A8%99\" >10. SURMOUNT-4\u306e\u4e8b\u5f8c\u89e3\u6790\uff1a\u623b\u308a\u5e45\u3068\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/hanachan.org\/?p=116\/#%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-6\" >\u7814\u7a76\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/hanachan.org\/?p=116\/#11_%E5%AE%9F%E5%8B%99%E7%9A%84%E3%81%AA%E7%B5%90%E8%AB%96%EF%BC%9A%E7%9F%AD%E6%9C%9F%E3%81%A7%E4%BD%BF%E3%81%A3%E3%81%A6%E7%B5%82%E3%82%8F%E3%82%8A%E3%80%81%E3%81%A7%E3%81%AF%E7%B6%AD%E6%8C%81%E3%81%8C%E9%9B%A3%E3%81%97%E3%81%84\" >11. \u5b9f\u52d9\u7684\u306a\u7d50\u8ad6\uff1a\u77ed\u671f\u3067\u4f7f\u3063\u3066\u7d42\u308f\u308a\u3001\u3067\u306f\u7dad\u6301\u304c\u96e3\u3057\u3044<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/hanachan.org\/?p=116\/#12_%E3%81%BE%E3%81%A8%E3%82%81\" >12. \u307e\u3068\u3081<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/hanachan.org\/?p=116\/#%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\" >\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"TLDR\"><\/span>TL;DR<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>BMJ\u306b\u63b2\u8f09\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001GLP-1\u85ac\u306a\u3069\u306e\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u308b\u3068\u3001\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u305d\u308c\u3092\u305d\u306e\u307e\u307e<strong>\u300cGLP-1\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d<\/strong>\u3068\u53d7\u3051\u53d6\u308b\u306b\u306f\u3001\u5c11\u3057\u614e\u91cd\u306a\u898b\u65b9\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>GLP-1\u85ac\u3084\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u901a\u5e38\u306e\u751f\u6d3b\u6539\u5584\u3088\u308a\u3082\u5927\u304d\u304f\u4f53\u91cd\u3092\u4e0b\u3052\u3084\u3059\u3044\u305f\u3081\u3001\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306b\u623b\u308bkg\u6570\u3082\u5927\u304d\u304f\u898b\u3048\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u672c\u5f53\u306b\u898b\u305f\u3044\u306e\u306f\u3001\u300c\u4f55kg\u623b\u3063\u305f\u304b\u300d\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u5927\u5207\u306a\u306e\u306f\u3001<\/p>\n<ul>\n<li>\u958b\u59cbBMI<\/li>\n<li>\u6700\u4f4eBMI<\/li>\n<li>\u6700\u7d42BMI<\/li>\n<\/ul>\n<p>\u306e\u6d41\u308c\u3067\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u85ac\u3067\u3069\u3053\u307e\u3067\u4e0b\u304c\u308a\u3001\u3084\u3081\u305f\u5f8c\u306b\u3069\u3053\u3078\u843d\u3061\u7740\u3044\u305f\u306e\u304b\u3092\u898b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>GLP-1\u85ac\u306f\u5927\u304d\u304f\u75e9\u305b\u3084\u3059\u3044\u4e00\u65b9\u3067\u3001\u3084\u3081\u308b\u3068\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u3082\u7814\u7a76\u4e0a\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3060\u304b\u3089\u3053\u305d\u3001\u77ed\u671f\u7684\u306b\u4f53\u91cd\u3092\u843d\u3068\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u85ac\u3092\u4f7f\u3063\u3066\u3044\u308b\u9593\u306b\u3001\u7dad\u6301\u3067\u304d\u308b\u98df\u4e8b\u91cf\u30fb\u904b\u52d5\u7fd2\u6163\u30fb\u76ee\u6a19BMI\u3092\u8003\u3048\u3066\u304a\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"1_%E3%81%AF%E3%81%98%E3%82%81%E3%81%AB%EF%BC%9A%E3%80%8C%E3%83%AA%E3%83%90%E3%82%A6%E3%83%B3%E3%83%89%E3%81%97%E3%82%84%E3%81%99%E3%81%84%E3%80%8D%E3%81%A8%E3%81%84%E3%81%86%E8%A8%80%E8%91%89%E3%81%A0%E3%81%91%E3%81%A7%E5%88%A4%E6%96%AD%E3%81%97%E3%81%AA%E3%81%84%E3%81%9F%E3%82%81%E3%81%AB\"><\/span>1. \u306f\u3058\u3081\u306b\uff1a\u300c\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d\u3068\u3044\u3046\u8a00\u8449\u3060\u3051\u3067\u5224\u65ad\u3057\u306a\u3044\u305f\u3081\u306b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6700\u8fd1\u3001\u300cGLP-1\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u304c\u623b\u308b\u300d\u300c\u30ea\u30d0\u30a6\u30f3\u30c9\u304c\u65e9\u3044\u300d\u3068\u3044\u3063\u305f\u7814\u7a76\u7d39\u4ecb\u3092\u898b\u304b\u3051\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u305f\u3057\u304b\u306b\u3001BMJ\u306b\u63b2\u8f09\u3055\u308c\u305f\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306b\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u3053\u306e\u7814\u7a76\u3092\u305d\u306e\u307e\u307e<strong>\u300cGLP-1\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u85ac\u300d<\/strong>\u3068\u53d7\u3051\u53d6\u308b\u306b\u306f\u3001\u5c11\u3057\u614e\u91cd\u306a\u89e3\u91c8\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u306a\u305c\u306a\u3089\u3001GLP-1\u85ac\u3084\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u901a\u5e38\u306e\u751f\u6d3b\u6539\u5584\u3088\u308a\u3082\u5927\u304d\u304f\u4f53\u91cd\u3092\u4e0b\u3052\u3084\u3059\u3044\u85ac\u3060\u304b\u3089\u3067\u3059\u3002<\/p>\n<p>\u5927\u304d\u304f\u75e9\u305b\u308b\u85ac\u3060\u304b\u3089\u3053\u305d\u3001\u3084\u3081\u305f\u5f8c\u306b\u300c\u623b\u3063\u305fkg\u6570\u300d\u3082\u5927\u304d\u304f\u898b\u3048\u3084\u3059\u3044\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u305d\u306e\u70b9\u3092\u4e01\u5be7\u306b\u6574\u7406\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>West et al.\uff082026\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aWeight regain after cessation of medication for weight management: systematic review and meta-analysis<br \/>\n\u63b2\u8f09\u8a8c\uff1aThe BMJ, 2026;392:e085304<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u30fb\u30e1\u30bf\u89e3\u6790<br \/>\n\u5bfe\u8c61\uff1a37\u7814\u7a76\u300163\u4ecb\u5165\u7fa4\u30019,341\u4eba<br \/>\nDOI\uff1a10.1136\/bmj-2025-085304<br \/>\nURL\uff1a<a href=\"https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304\" target=\"_blank\" rel=\"noopener\">https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"2_BMJ%E7%A0%94%E7%A9%B6%E3%81%8C%E7%A4%BA%E3%81%97%E3%81%9F%E3%81%93%E3%81%A8%EF%BC%9A%E8%96%AC%E3%82%92%E3%82%84%E3%82%81%E3%82%8B%E3%81%A8%E4%BD%93%E9%87%8D%E3%81%AF%E6%88%BB%E3%82%8A%E3%82%84%E3%81%99%E3%81%84\"><\/span>2. BMJ\u7814\u7a76\u304c\u793a\u3057\u305f\u3053\u3068\uff1a\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u306f\u623b\u308a\u3084\u3059\u3044<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u307e\u305a\u3001\u7814\u7a76\u304c\u793a\u3057\u3066\u3044\u308b\u5185\u5bb9\u305d\u306e\u3082\u306e\u306f\u3001\u3068\u3066\u3082\u5927\u5207\u3067\u3059\u3002<\/p>\n<p>BMJ\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u300137\u7814\u7a76\u30fb9,341\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u6e1b\u91cf\u85ac\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u306e\u4f53\u91cd\u306e\u623b\u308a\u65b9\u3092\u5206\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306e\u4f53\u91cd\u518d\u5897\u52a0\u306f\u3001\u5e73\u5747\u3067\u67080.4kg\u7a0b\u5ea6\u3068\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3084\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306e\u3088\u3046\u306a\u65b0\u3057\u3044\u85ac\u3067\u306f\u3001\u67080.8kg\u7a0b\u5ea6\u3068\u3001\u3088\u308a\u901f\u304f\u623b\u308b\u50be\u5411\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306e\u4f53\u91cd\u306e\u623b\u308a\u306f\u3001\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u884c\u52d5\u7642\u6cd5\u304c\u7d42\u308f\u3063\u305f\u5f8c\u3088\u308a\u3082\u901f\u3044\u3001\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u3053\u3060\u3051\u3092\u898b\u308b\u3068\u3001\u305f\u3057\u304b\u306b<strong>\u300cGLP-1\u85ac\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u306e\u3067\u306f\uff1f\u300d<\/strong>\u3068\u611f\u3058\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-2\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>West et al.\uff082026\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aWeight regain after cessation of medication for weight management: systematic review and meta-analysis<br \/>\n\u63b2\u8f09\u8a8c\uff1aThe BMJ, 2026;392:e085304<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u30fb\u30e1\u30bf\u89e3\u6790<br \/>\n\u691c\u7d22\u5bfe\u8c61\uff1aMedline\u3001Embase\u3001PsycINFO\u3001CINAHL\u3001Cochrane\u3001Web of Science\u3001\u8a66\u9a13\u767b\u9332\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306a\u3069<br \/>\n\u691c\u7d22\u671f\u9593\uff1a\u5404\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u958b\u59cb\u6642\u70b9\u304b\u30892025\u5e742\u6708\u307e\u3067<br \/>\n\u4e3b\u306a\u8a55\u4fa1\u9805\u76ee\uff1a\u6e1b\u91cf\u85ac\u4e2d\u6b62\u5f8c\u306e\u4f53\u91cd\u518d\u5897\u52a0\u901f\u5ea6\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30de\u30fc\u30ab\u30fc\u306e\u5909\u5316<br \/>\n\u4e3b\u306a\u7d50\u679c\uff1a\u6e1b\u91cf\u85ac\u4e2d\u6b62\u5f8c\u306e\u4f53\u91cd\u518d\u5897\u52a0\u306f\u5e73\u57470.4kg\/\u6708\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u30fb\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3067\u306f0.8kg\/\u6708\u3002<br \/>\nDOI\uff1a10.1136\/bmj-2025-085304<br \/>\nURL\uff1a<a href=\"https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304\" target=\"_blank\" rel=\"noopener\">https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304<\/a><br \/>\nPubMed\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41500720\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41500720\/<\/a><br \/>\nBMJ Group\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a<a href=\"https:\/\/bmjgroup.com\/stopping-weight-loss-drugs-linked-to-weight-regain-and-reversal-of-heart-health-markers\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bmjgroup.com\/stopping-weight-loss-drugs-linked-to-weight-regain-and-reversal-of-heart-health-markers\/<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"3_%E3%81%9F%E3%81%A0%E3%81%97%E3%80%81%E8%96%AC%E3%81%AE%E6%96%B9%E3%81%8C%E3%81%9D%E3%82%82%E3%81%9D%E3%82%82%E5%A4%A7%E3%81%8D%E3%81%8F%E7%97%A9%E3%81%9B%E3%82%84%E3%81%99%E3%81%84\"><\/span>3. \u305f\u3060\u3057\u3001\u85ac\u306e\u65b9\u304c\u305d\u3082\u305d\u3082\u5927\u304d\u304f\u75e9\u305b\u3084\u3059\u3044<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u3053\u3053\u304c\u3001\u3053\u306e\u8a18\u4e8b\u3067\u6700\u3082\u5927\u5207\u306a\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n<p>\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3084\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u901a\u5e38\u306e\u751f\u6d3b\u6539\u5584\u3088\u308a\u3082\u5927\u304d\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u85ac\u3067\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306b\u300c\u6708\u306b\u4f55kg\u623b\u3063\u305f\u304b\u300d\u3060\u3051\u3092\u898b\u308b\u3068\u3001\u85ac\u306b\u3088\u308b\u30ea\u30d0\u30a6\u30f3\u30c9\u304c\u5fc5\u8981\u4ee5\u4e0a\u306b\u5927\u304d\u304f\u898b\u3048\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>Reuters\u306e\u8a18\u4e8b\u3067\u3082\u3001\u7814\u7a76\u8005\u306f\u6b21\u306e\u3088\u3046\u306a\u8da3\u65e8\u306e\u8aac\u660e\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<blockquote><p>\n\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3084\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3067\u306f\u3001\u4f53\u91cd\u304c\u623b\u308b\u30b9\u30d4\u30fc\u30c9\u306f\u901f\u3044\u3002<br \/>\n\u3051\u308c\u3069\u3001\u305d\u3082\u305d\u3082\u6700\u521d\u306b\u5927\u304d\u304f\u75e9\u305b\u3066\u3044\u308b\u305f\u3081\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u4f53\u91cd\u306b\u623b\u308b\u307e\u3067\u306e\u671f\u9593\u306f\u3001\u4ed6\u306e\u85ac\u3068\u5927\u304d\u304f\u5909\u308f\u3089\u306a\u3044\u3002\n<\/p><\/blockquote>\n<p>\u3064\u307e\u308a\u3001\u85ac\u3067\u6df1\u304f\u4f53\u91cd\u3092\u4e0b\u3052\u305f\u3076\u3093\u3001\u3084\u3081\u305f\u5f8c\u306e\u623b\u308a\u5e45\u3082\u5927\u304d\u304f\u898b\u3048\u3084\u3059\u3044\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%83%85%E5%A0%B1\"><\/span>\u53c2\u8003\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Reuters\uff082026\u5e741\u67087\u65e5\uff09<\/strong><br \/>\n\u8a18\u4e8b\u540d\uff1aLess than two years after stopping obesity drugs, weight and health issues return, study finds<br \/>\n\u5185\u5bb9\uff1aBMJ\u7814\u7a76\u306b\u3064\u3044\u3066\u3001\u6e1b\u91cf\u85ac\u4e2d\u6b62\u5f8c\u306e\u4f53\u91cd\u518d\u5897\u52a0\u3068\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u30de\u30fc\u30ab\u30fc\u306e\u53cd\u8ee2\u3092\u7d39\u4ecb\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u30fb\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u623b\u308a\u901f\u5ea6\u304c\u901f\u3044\u4e00\u65b9\u3001\u521d\u671f\u6e1b\u91cf\u3082\u5927\u304d\u3044\u305f\u3081\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u4f53\u91cd\u3078\u623b\u308b\u307e\u3067\u306e\u6642\u9593\u306f\u4ed6\u85ac\u5264\u3068\u8fd1\u3044\u3068\u3044\u3046\u7814\u7a76\u8005\u30b3\u30e1\u30f3\u30c8\u3092\u63b2\u8f09\u3002<br \/>\nURL\uff1a<a href=\"https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/less-than-two-years-after-stopping-obesity-drugs-weight-health-issues-return-2026-01-07\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/less-than-two-years-after-stopping-obesity-drugs-weight-health-issues-return-2026-01-07\/<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"4_%E3%80%8C%E4%BD%95kg%E6%88%BB%E3%81%A3%E3%81%9F%E3%81%8B%E3%80%8D%E3%81%A0%E3%81%91%E3%81%A7%E3%81%AF%E8%A6%8B%E3%81%88%E3%81%AA%E3%81%84%E3%81%93%E3%81%A8\"><\/span>4. \u300c\u4f55kg\u623b\u3063\u305f\u304b\u300d\u3060\u3051\u3067\u306f\u898b\u3048\u306a\u3044\u3053\u3068<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u5c11\u3057\u4f8b\u3067\u8003\u3048\u3066\u307f\u307e\u3059\u3002<\/p>\n<p>70kg\u306e\u4eba\u304c\u3001\u85ac\u306750kg\u307e\u3067\u843d\u3061\u3066\u3001\u305d\u306e\u5f8c65kg\u306b\u623b\u3063\u305f\u3068\u3057\u307e\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3067\u3001\u901a\u5e38\u306e\u30c0\u30a4\u30a8\u30c3\u30c8\u306760kg\u307e\u3067\u843d\u3061\u3066\u3001\u305d\u306e\u5f8c65kg\u306b\u623b\u3063\u305f\u4eba\u304c\u3044\u305f\u3068\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u5834\u5408\u3001\u6700\u7d42\u4f53\u91cd\u306f\u3069\u3061\u3089\u308265kg\u3067\u3059\u3002<\/p>\n<p>\u3067\u3082\u3001\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u898b\u308b\u3068\u3001<\/p>\n<ul>\n<li>50kg\u307e\u3067\u843d\u3061\u305f\u4eba\u306f\u300115kg\u623b\u3063\u305f<\/li>\n<li>60kg\u307e\u3067\u843d\u3061\u305f\u4eba\u306f\u30015kg\u623b\u3063\u305f<\/li>\n<\/ul>\n<p>\u3068\u3044\u3046\u898b\u3048\u65b9\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3060\u3051\u3092\u898b\u308b\u3068\u3001\u85ac\u3067\u75e9\u305b\u305f\u4eba\u306e\u65b9\u304c\u5927\u304d\u304f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u305f\u3088\u3046\u306b\u611f\u3058\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u5b9f\u969b\u306b\u306f\u3069\u3061\u3089\u3082\u6700\u7d42\u7684\u306b\u306f65kg\u306b\u843d\u3061\u7740\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u85ac\u3067\u3088\u308a\u6df1\u304f\u4f53\u91cd\u3092\u4e0b\u3052\u305f\u305f\u3081\u306b\u3001\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u306e\u623b\u308a\u5e45\u304c\u5927\u304d\u304f\u898b\u3048\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"5_%E3%80%8C%E6%88%BB%E3%82%8A%E5%B9%85_%C3%B7_%E7%97%A9%E3%81%9B%E5%B9%85%E3%80%8D%E3%81%A7%E8%A6%8B%E3%81%A6%E3%82%82%E3%80%81%E3%81%BE%E3%81%A0%E5%8D%81%E5%88%86%E3%81%A8%E3%81%AF%E8%A8%80%E3%81%88%E3%81%AA%E3%81%84\"><\/span>5. \u300c\u623b\u308a\u5e45 \u00f7 \u75e9\u305b\u5e45\u300d\u3067\u898b\u3066\u3082\u3001\u307e\u3060\u5341\u5206\u3068\u306f\u8a00\u3048\u306a\u3044<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u3067\u306f\u3001\u300c\u4f55kg\u623b\u3063\u305f\u304b\u300d\u3067\u306f\u306a\u304f\u3001\u300c\u6e1b\u3063\u305f\u5206\u306e\u4f55\uff05\u304c\u623b\u3063\u305f\u304b\u300d\u3067\u898b\u308c\u3070\u3088\u3044\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n<p>\u3053\u308c\u306f\u4e00\u898b\u3001\u516c\u5e73\u306a\u898b\u65b9\u306b\u601d\u3048\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3060\u3051\u3067\u3082\u5341\u5206\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p>70kg\u304b\u308950kg\u307e\u3067\u843d\u3061\u306665kg\u306b\u623b\u3063\u305f\u5834\u5408\u300120kg\u75e9\u305b\u306615kg\u623b\u3063\u305f\u306e\u3067\u3001\u623b\u308a\u7387\u306f75%\u3067\u3059\u3002<\/p>\n<p>70kg\u304b\u308960kg\u307e\u3067\u843d\u3061\u306665kg\u306b\u623b\u3063\u305f\u5834\u5408\u300110kg\u75e9\u305b\u30665kg\u623b\u3063\u305f\u306e\u3067\u3001\u623b\u308a\u7387\u306f50%\u3067\u3059\u3002<\/p>\n<p>\u6570\u5b57\u3060\u3051\u3092\u898b\u308b\u3068\u3001\u524d\u8005\u306e\u65b9\u304c\u5927\u304d\u304f\u623b\u3063\u305f\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001\u6700\u7d42\u4f53\u91cd\u306f\u3069\u3061\u3089\u308265kg\u3067\u3059\u3002<\/p>\n<p>\u540c\u3058\u751f\u6d3b\u306b\u623b\u308a\u3001\u540c\u3058\u4f53\u91cd\u306b\u843d\u3061\u7740\u3044\u305f\u306e\u3067\u3042\u308c\u3070\u300175%\u623b\u3063\u305f\u4eba\u306e\u65b9\u304c\u300c\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u4f53\u8cea\u306b\u306a\u3063\u305f\u300d\u3068\u307e\u3067\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p>\u5358\u306b\u3001\u3088\u308a\u4f4e\u3044\u4f53\u91cd\u307e\u3067\u4e00\u5ea6\u843d\u3061\u305f\u305f\u3081\u306b\u3001\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u898b\u305f\u623b\u308a\u7387\u304c\u5927\u304d\u304f\u898b\u3048\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"6_%E6%9C%AC%E5%BD%93%E3%81%AB%E8%A6%8B%E3%81%9F%E3%81%84%E3%81%AE%E3%81%AF%E3%80%81BMI%E3%81%AE%E6%B5%81%E3%82%8C\"><\/span>6. \u672c\u5f53\u306b\u898b\u305f\u3044\u306e\u306f\u3001BMI\u306e\u6d41\u308c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u4f53\u91cd\u3092kg\u3060\u3051\u3067\u898b\u308b\u3053\u3068\u306b\u3082\u3001\u5c11\u3057\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>100kg\u306e\u4eba\u304c10kg\u75e9\u305b\u308b\u306e\u3068\u300150kg\u306e\u4eba\u304c10kg\u75e9\u305b\u308b\u306e\u3067\u306f\u3001\u610f\u5473\u304c\u307e\u3063\u305f\u304f\u9055\u3044\u307e\u3059\u3002<\/p>\n<p>\u540c\u305810kg\u6e1b\u3067\u3082\u3001\u524d\u8005\u306f10%\u6e1b\u91cf\u3001\u5f8c\u8005\u306f20%\u6e1b\u91cf\u3067\u3059\u3002\u5065\u5eb7\u4e0a\u306e\u610f\u5473\u3082\u3001\u8eab\u4f53\u3078\u306e\u8ca0\u62c5\u3082\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n<p>\u3060\u304b\u3089\u3001GLP-1\u85ac\u306e\u30ea\u30d0\u30a6\u30f3\u30c9\u3092\u8003\u3048\u308b\u306a\u3089\u3001\u672c\u6765\u306f\u6b21\u306e3\u3064\u3092\u898b\u308b\u65b9\u304c\u308f\u304b\u308a\u3084\u3059\u3044\u3067\u3059\u3002<\/p>\n<ul>\n<li>\u958b\u59cbBMI<\/li>\n<li>\u6700\u4f4eBMI<\/li>\n<li>\u6700\u7d42BMI<\/li>\n<\/ul>\n<p>\u3064\u307e\u308a\u3001\u300c\u3069\u306eBMI\u304b\u3089\u59cb\u307e\u3063\u305f\u306e\u304b\u300d\u300c\u85ac\u3067\u3069\u3053\u307e\u3067\u4e0b\u304c\u3063\u305f\u306e\u304b\u300d\u300c\u85ac\u3092\u3084\u3081\u305f\u5f8c\u3001\u3069\u3053\u306b\u843d\u3061\u7740\u3044\u305f\u306e\u304b\u300d\u3092\u898b\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u4f55kg\u623b\u3063\u305f\u304b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u6700\u7d42\u7684\u306b\u3001\u958b\u59cb\u6642\u70b9\u3088\u308a\u3069\u308c\u304f\u3089\u3044\u826f\u3044\u72b6\u614b\u3092\u7dad\u6301\u3067\u304d\u3066\u3044\u308b\u306e\u304b\u3002<\/p>\n<p>\u3053\u3053\u3092\u898b\u308b\u65b9\u304c\u3001\u5b9f\u614b\u306b\u8fd1\u3044\u8a55\u4fa1\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"7_BMJ%E7%A0%94%E7%A9%B6%E3%81%AE%E9%99%90%E7%95%8C%EF%BC%9ABMI%E3%81%AE%E6%B5%81%E3%82%8C%E3%82%92%E4%B8%AD%E5%BF%83%E3%81%AB%E8%A6%8B%E3%81%9F%E7%A0%94%E7%A9%B6%E3%81%A7%E3%81%AF%E3%81%AA%E3%81%84\"><\/span>7. BMJ\u7814\u7a76\u306e\u9650\u754c\uff1aBMI\u306e\u6d41\u308c\u3092\u4e2d\u5fc3\u306b\u898b\u305f\u7814\u7a76\u3067\u306f\u306a\u3044<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>BMJ\u7814\u7a76\u306f\u3001\u3068\u3066\u3082\u91cd\u8981\u306a\u7814\u7a76\u3067\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u4e3b\u306a\u5206\u6790\u306fkg\u30d9\u30fc\u30b9\u306e\u4f53\u91cd\u518d\u5897\u52a0\u3067\u3042\u308a\u3001\u300c\u958b\u59cbBMI \u2192 \u6700\u4f4eBMI \u2192 \u6700\u7d42BMI\u300d\u3068\u3044\u3046\u6d41\u308c\u3092\u4e2d\u5fc3\u306b\u3057\u305f\u6bd4\u8f03\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u307e\u305f\u3001\u85ac\u3092\u3084\u3081\u305f\u5f8c\u3068\u3001\u884c\u52d5\u7642\u6cd5\u304c\u7d42\u308f\u3063\u305f\u5f8c\u306e\u6bd4\u8f03\u3082\u3001\u5b8c\u5168\u306b\u540c\u3058\u6761\u4ef6\u3067\u300c\u85ac\u3060\u3051\u300d\u3092\u5dee\u5206\u306b\u3057\u305f\u6bd4\u8f03\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>BMJ\u5074\u3082\u3001\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3084\u8cea\u306b\u3070\u3089\u3064\u304d\u304c\u3042\u308b\u3053\u3068\u3001\u65b0\u3057\u3044GLP-1\u7cfb\u85ac\u5264\u3092\u6271\u3063\u305f\u7814\u7a76\u304c\u9650\u3089\u308c\u308b\u3053\u3068\u3001\u6700\u5927\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c12\u304b\u6708\u3067\u3042\u308b\u3053\u3068\u3092\u9650\u754c\u3068\u3057\u3066\u6319\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u3053\u306e\u7814\u7a76\u304b\u3089\u8a00\u3048\u308b\u306e\u306f\u3001\u307e\u305a\u306f\u6b21\u306e\u3068\u3053\u308d\u307e\u3067\u3067\u3059\u3002<\/p>\n<ul>\n<li>\u300c\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u306f\u623b\u308a\u3084\u3059\u3044\u300d<\/li>\n<li>\u300c\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306e\u623b\u308a\u306f\u3001\u884c\u52d5\u7642\u6cd5\u5f8c\u3088\u308a\u901f\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u300d<\/li>\n<\/ul>\n<p>\u4e00\u65b9\u3067\u3001<\/p>\n<ul>\n<li>\u300cGLP-1\u85ac\u304c\u7279\u5225\u306b\u30ea\u30d0\u30a6\u30f3\u30c9\u4f53\u8cea\u3092\u4f5c\u308b\u300d<\/li>\n<li>\u300c\u85ac\u3067\u75e9\u305b\u305f\u4eba\u306f\u3001\u901a\u5e38\u30c0\u30a4\u30a8\u30c3\u30c8\u3088\u308a\u672c\u8cea\u7684\u306b\u623b\u308a\u3084\u3059\u3044\u300d<\/li>\n<\/ul>\n<p>\u3068\u307e\u3067\u8a00\u3044\u5207\u308b\u306b\u306f\u3001\u614e\u91cd\u306a\u898b\u65b9\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-3\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>West et al.\uff082026\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aWeight regain after cessation of medication for weight management: systematic review and meta-analysis<br \/>\n\u63b2\u8f09\u8a8c\uff1aThe BMJ, 2026;392:e085304<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u30fb\u30e1\u30bf\u89e3\u6790<br \/>\n\u5bfe\u8c61\uff1a37\u7814\u7a76\u300163\u4ecb\u5165\u7fa4\u30019,341\u4eba<br \/>\n\u5e73\u5747\u6cbb\u7642\u671f\u9593\uff1a39\u9031<br \/>\n\u5e73\u5747\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\uff1a32\u9031<br \/>\n\u4e3b\u306a\u9650\u754c\uff1a\u65b0\u3057\u3044GLP-1\u7cfb\u30fb\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u7cfb\u306e\u7814\u7a76\u306f8\u4ef6\u306b\u9650\u3089\u308c\u3001\u85ac\u5264\u4e2d\u6b62\u5f8c\u306e\u6700\u5927\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306f12\u304b\u6708\u3002\u85ac\u5264\u7814\u7a76\u3068\u884c\u52d5\u7642\u6cd5\u7814\u7a76\u306e\u6bd4\u8f03\u306f\u9593\u63a5\u6bd4\u8f03\u3002<br \/>\nDOI\uff1a10.1136\/bmj-2025-085304<br \/>\nURL\uff1a<a href=\"https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304\" target=\"_blank\" rel=\"noopener\">https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"8_%E3%82%BB%E3%83%9E%E3%82%B0%E3%83%AB%E3%83%81%E3%83%89%E4%B8%AD%E6%AD%A2%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%EF%BC%9ASTEP_1%E5%BB%B6%E9%95%B7%E8%A9%A6%E9%A8%93\"><\/span>8. \u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u4e2d\u6b62\u5f8c\u306e\u7814\u7a76\uff1aSTEP 1\u5ef6\u9577\u8a66\u9a13<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u30bb\u30de\u30b0\u30eb\u30c1\u30c92.4mg\u306eSTEP 1\u5ef6\u9577\u8a66\u9a13\u3067\u306f\u300168\u9031\u9593\u306e\u6cbb\u7642\u5f8c\u306b\u85ac\u3068\u751f\u6d3b\u4ecb\u5165\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u30011\u5e74\u3067\u6e1b\u91cf\u5206\u306e\u7d043\u5206\u306e2\u3092\u53d6\u308a\u623b\u3057\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u3001\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u3092\u793a\u3059\u3001\u3068\u3066\u3082\u91cd\u8981\u306a\u30c7\u30fc\u30bf\u3067\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u3053\u306e\u30c7\u30fc\u30bf\u3082\u3001\u300c\u85ac\u3067\u6df1\u304f\u4e0b\u304c\u3063\u305f\u4f53\u91cd\u304c\u3001\u85ac\u306a\u3057\u306e\u751f\u6d3b\u3067\u7dad\u6301\u3067\u304d\u308b\u6c34\u6e96\u3078\u623b\u3063\u305f\u300d\u3068\u8aad\u3080\u4f59\u5730\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3060\u304b\u3089\u3053\u3053\u3067\u3082\u3001\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u4f55kg\u623b\u3063\u305f\u304b\u3060\u3051\u3067\u306a\u304f\u3001\u958b\u59cb\u6642\u70b9\u304b\u3089\u898b\u3066\u3001\u6700\u7d42\u7684\u306b\u3069\u308c\u304f\u3089\u3044\u6539\u5584\u304c\u6b8b\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u898b\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-4\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Wilding et al.\uff082022\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aWeight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension<br \/>\n\u63b2\u8f09\u8a8c\uff1aDiabetes, Obesity and Metabolism, 2022;24(8):1553\u20131564<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1aSTEP 1\u8a66\u9a13\u306e\u5ef6\u9577\u89e3\u6790<br \/>\n\u5bfe\u8c61\uff1a\u5ef6\u9577\u89e3\u6790327\u4eba<br \/>\n\u85ac\u5264\uff1a\u30bb\u30de\u30b0\u30eb\u30c1\u30c92.4mg \u90311\u56de\u76ae\u4e0b\u6ce8\u5c04<br \/>\n\u6cbb\u7642\u671f\u9593\uff1a68\u9031<br \/>\n\u4e2d\u6b62\u5f8c\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\uff1a52\u9031<br \/>\n\u4e3b\u306a\u7d50\u679c\uff1a\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7fa4\u306f68\u9031\u6642\u70b9\u3067\u5e73\u574717.3%\u6e1b\u91cf\u3002\u305d\u306e\u5f8c\u3001\u85ac\u3068\u751f\u6d3b\u4ecb\u5165\u3092\u4e2d\u6b62\u3057\u3001120\u9031\u6642\u70b9\u306711.6\u30dd\u30a4\u30f3\u30c8\u5206\u304c\u623b\u3063\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u958b\u59cb\u6642\u70b9\u304b\u3089\u306f5.6%\u4f4e\u3044\u4f53\u91cd\u304c\u6b8b\u3063\u305f\u3002<br \/>\nDOI\uff1a10.1111\/dom.14725<br \/>\nPubMed\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35441470\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35441470\/<\/a><br \/>\n\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9542252\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9542252\/<\/a><br \/>\nClinicalTrials.gov\uff1aNCT03548935<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"9_%E3%83%81%E3%83%AB%E3%82%BC%E3%83%91%E3%83%81%E3%83%89%E4%B8%AD%E6%AD%A2%E5%BE%8C%E3%81%AE%E7%A0%94%E7%A9%B6%EF%BC%9ASURMOUNT-4\"><\/span>9. \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u4e2d\u6b62\u5f8c\u306e\u7814\u7a76\uff1aSURMOUNT-4<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306eSURMOUNT-4\u8a66\u9a13\u3067\u3082\u3001\u85ac\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u306b\u4f53\u91cd\u304c\u623b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>SURMOUNT-4\u306f\u3001\u307e\u305a36\u9031\u9593\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3092\u4f7f\u3044\u3001\u305d\u306e\u5f8c\u3001\u85ac\u3092\u7d9a\u3051\u308b\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u3078\u5207\u308a\u66ff\u3048\u308b\u7fa4\u306b\u5206\u3051\u305f\u8a66\u9a13\u3067\u3059\u3002<\/p>\n<p>36\u9031\u6642\u70b9\u3067\u3001\u53c2\u52a0\u8005\u306f\u5e73\u574720.9%\u306e\u4f53\u91cd\u6e1b\u5c11\u3092\u7d4c\u9a13\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u5f8c\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3092\u7d9a\u3051\u305f\u7fa4\u3067\u306f\u3055\u3089\u306b\u4f53\u91cd\u304c\u6e1b\u308a\u307e\u3057\u305f\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u3078\u5207\u308a\u66ff\u3048\u305f\u7fa4\u3067\u306f\u4f53\u91cd\u304c\u623b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u8a66\u9a13\u3067\u3082\u3001\u98df\u4e8b\u30fb\u904b\u52d5\u6307\u5c0e\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u5358\u306a\u308b\u300c\u85ac\u3060\u3051\u3067\u75e9\u305b\u3066\u3001\u85ac\u3092\u3084\u3081\u305f\u3089\u623b\u3063\u305f\u300d\u3068\u3044\u3046\u8a71\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u751f\u6d3b\u6307\u5c0e\u304c\u3042\u3063\u3066\u3082\u623b\u3063\u305f\u3001\u3068\u3044\u3046\u70b9\u306f\u5927\u5207\u3067\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3067\u3001\u3053\u3053\u3067\u3082\u3084\u306f\u308a\u3001\u300c\u3069\u3053\u307e\u3067BMI\u304c\u4e0b\u304c\u308a\u3001\u6700\u7d42\u7684\u306b\u3069\u3053\u306b\u843d\u3061\u7740\u3044\u305f\u306e\u304b\u300d\u3092\u898b\u306a\u3044\u3068\u3001\u30ea\u30d0\u30a6\u30f3\u30c9\u306e\u610f\u5473\u3092\u6b63\u78ba\u306b\u306f\u8a55\u4fa1\u3057\u306b\u304f\u3044\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-5\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Aronne et al.\uff082024\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aContinued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial<br \/>\n\u63b2\u8f09\u8a8c\uff1aJAMA, 2024;331(1):38\u201348<br \/>\n\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff1a2023\u5e7412\u670811\u65e5<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u7b2c3\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u4e2d\u6b62\u8a66\u9a13<br \/>\n\u5bfe\u8c61\uff1a670\u4eba<br \/>\n\u85ac\u5264\uff1a\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9 10mg\u307e\u305f\u306f15mg\u3001\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04<br \/>\n\u8a66\u9a13\u671f\u9593\uff1a36\u9031\u9593\u306e\u30aa\u30fc\u30d7\u30f3\u30e9\u30d9\u30eb\u5c0e\u5165\u671f\u9593\u3001\u305d\u306e\u5f8c52\u9031\u9593\u306e\u4e8c\u91cd\u76f2\u691c\u671f\u9593<br \/>\n\u4e3b\u306a\u7d50\u679c\uff1a36\u9031\u6642\u70b9\u3067\u5e73\u574720.9%\u6e1b\u91cf\u3002\u305d\u306e\u5f8c\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3092\u7d9a\u3051\u305f\u7fa4\u306f\u8ffd\u52a0\u30675.5%\u6e1b\u91cf\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u3078\u5207\u308a\u66ff\u3048\u305f\u7fa4\u306f14.0%\u4f53\u91cd\u304c\u623b\u3063\u305f\u3002<br \/>\nDOI\uff1a10.1001\/jama.2023.24945<br \/>\nURL\uff1a<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2812936\" target=\"_blank\" rel=\"noopener\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2812936<\/a><br \/>\nClinicalTrials.gov\uff1a<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04660643\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT04660643<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"10_SURMOUNT-4%E3%81%AE%E4%BA%8B%E5%BE%8C%E8%A7%A3%E6%9E%90%EF%BC%9A%E6%88%BB%E3%82%8A%E5%B9%85%E3%81%A8%E5%BF%83%E8%A1%80%E7%AE%A1%E4%BB%A3%E8%AC%9D%E6%8C%87%E6%A8%99\"><\/span>10. SURMOUNT-4\u306e\u4e8b\u5f8c\u89e3\u6790\uff1a\u623b\u308a\u5e45\u3068\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>SURMOUNT-4\u306e\u4e8b\u5f8c\u89e3\u6790\u3067\u306f\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3092\u4e2d\u6b62\u3057\u305f\u5f8c\u3001\u4f53\u91cd\u304c\u623b\u3063\u305f\u4eba\u307b\u3069\u3001\u8840\u5727\u30fb\u8840\u7cd6\u30fb\u8102\u8cea\u306a\u3069\u306e\u6539\u5584\u3082\u53cd\u8ee2\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u89e3\u6790\u3067\u306f\u300136\u9031\u9593\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u6cbb\u7642\u306710%\u4ee5\u4e0a\u6e1b\u91cf\u3057\u305f\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001\u30d7\u30e9\u30bb\u30dc\u3078\u5207\u308a\u66ff\u3048\u3089\u308c\u305f\u4eba\u3092\u5bfe\u8c61\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4e2d\u6b62\u5f8c1\u5e74\u3067\u3001\u591a\u304f\u306e\u53c2\u52a0\u8005\u304c\u521d\u671f\u6e1b\u91cf\u5206\u306e25%\u4ee5\u4e0a\u3092\u53d6\u308a\u623b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u4f53\u91cd\u306e\u623b\u308a\u304c\u5927\u304d\u3044\u4eba\u307b\u3069\u3001\u30a6\u30a8\u30b9\u30c8\u3001\u8840\u5727\u3001non-HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001HbA1c\u3001\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u306a\u3069\u306e\u6539\u5584\u304c\u623b\u308a\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u5358\u306b\u300c\u4f53\u91cd\u304c\u623b\u308b\u304b\u300d\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u300c\u4f53\u91cd\u304c\u623b\u308b\u3068\u3001\u5065\u5eb7\u6307\u6a19\u306e\u6539\u5584\u3082\u623b\u308a\u3084\u3059\u3044\u300d\u3068\u3044\u3046\u70b9\u3092\u793a\u3057\u3066\u3044\u308b\u610f\u5473\u3067\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%83%85%E5%A0%B1-6\"><\/span>\u7814\u7a76\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Horn et al.\uff082026\uff09<\/strong><br \/>\n\u8ad6\u6587\u540d\uff1aCardiometabolic Parameter Change by Weight Regain on Tirzepatide Withdrawal in Adults With Obesity: A Post Hoc Analysis of the SURMOUNT-4 Trial<br \/>\n\u63b2\u8f09\u8a8c\uff1aJAMA Internal Medicine, 2026;186(2):157\u2013167<br \/>\n\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff1a2025\u5e7411\u670824\u65e5<br \/>\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1aSURMOUNT-4\u8a66\u9a13\u306e\u4e8b\u5f8c\u89e3\u6790<br \/>\n\u5bfe\u8c61\uff1a308\u4eba<br \/>\n\u5bfe\u8c61\u6761\u4ef6\uff1a36\u9031\u9593\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u6cbb\u7642\u306710%\u4ee5\u4e0a\u6e1b\u91cf\u3057\u3001\u305d\u306e\u5f8c\u30d7\u30e9\u30bb\u30dc\u3078\u5207\u308a\u66ff\u3048\u3089\u308c\u305f\u53c2\u52a0\u8005<br \/>\n\u4e3b\u306a\u7d50\u679c\uff1a\u4e2d\u6b62\u5f8c1\u5e74\u4ee5\u5185\u306b\u3001\u53c2\u52a0\u8005\u306e\u591a\u304f\u304c\u521d\u671f\u6e1b\u91cf\u5206\u306e25%\u4ee5\u4e0a\u3092\u53d6\u308a\u623b\u3057\u305f\u3002\u4f53\u91cd\u306e\u623b\u308a\u304c\u5927\u304d\u3044\u307b\u3069\u3001\u30a6\u30a8\u30b9\u30c8\u3001\u8840\u5727\u3001non-HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001HbA1c\u3001\u7a7a\u8179\u6642\u30a4\u30f3\u30b9\u30ea\u30f3\u306a\u3069\u306e\u6539\u5584\u3082\u53cd\u8ee2\u3057\u3084\u3059\u304b\u3063\u305f\u3002<br \/>\nDOI\uff1a10.1001\/jamainternmed.2025.6112<br \/>\nURL\uff1a<a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2841273\" target=\"_blank\" rel=\"noopener\">https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2841273<\/a><br \/>\nClinicalTrials.gov\uff1a<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04660643\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT04660643<\/a><\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"11_%E5%AE%9F%E5%8B%99%E7%9A%84%E3%81%AA%E7%B5%90%E8%AB%96%EF%BC%9A%E7%9F%AD%E6%9C%9F%E3%81%A7%E4%BD%BF%E3%81%A3%E3%81%A6%E7%B5%82%E3%82%8F%E3%82%8A%E3%80%81%E3%81%A7%E3%81%AF%E7%B6%AD%E6%8C%81%E3%81%8C%E9%9B%A3%E3%81%97%E3%81%84\"><\/span>11. \u5b9f\u52d9\u7684\u306a\u7d50\u8ad6\uff1a\u77ed\u671f\u3067\u4f7f\u3063\u3066\u7d42\u308f\u308a\u3001\u3067\u306f\u7dad\u6301\u304c\u96e3\u3057\u3044<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u3053\u3053\u307e\u3067\u3092\u307e\u3068\u3081\u308b\u3068\u3001GLP-1\u85ac\u306b\u3064\u3044\u3066\u4e00\u756a\u6b63\u78ba\u306a\u8a00\u3044\u65b9\u306f\u3053\u3046\u3067\u3059\u3002<\/p>\n<p>GLP-1\u85ac\u306f\u3001\u901a\u5e38\u306e\u751f\u6d3b\u6539\u5584\u3088\u308a\u5927\u304d\u304f\u4f53\u91cd\u3092\u4e0b\u3052\u3084\u3059\u3044\u85ac\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u85ac\u3092\u3084\u3081\u305f\u5f8c\u306b\u623b\u308bkg\u6570\u3082\u5927\u304d\u304f\u898b\u3048\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u305d\u308c\u3092\u5358\u7d14\u306b\u300cGLP-1\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d\u3068\u8868\u73fe\u3057\u3066\u3057\u307e\u3046\u3068\u3001\u5c11\u3057\u4e00\u9762\u7684\u306a\u7406\u89e3\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u672c\u5f53\u306b\u898b\u308b\u3079\u304d\u306a\u306e\u306f\u3001<\/p>\n<ul>\n<li>\u958b\u59cbBMI<\/li>\n<li>\u6700\u4f4eBMI<\/li>\n<li>\u6700\u7d42BMI<\/li>\n<li>\u6700\u7d42\u7684\u306b\u3001\u958b\u59cb\u6642\u70b9\u304b\u3089\u3069\u308c\u3060\u3051\u6539\u5584\u304c\u6b8b\u3063\u305f\u304b<\/li>\n<\/ul>\n<p>\u3067\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3067\u3001\u85ac\u3092\u3084\u3081\u308b\u3068\u98df\u6b32\u3092\u6291\u3048\u308b\u4f5c\u7528\u304c\u5916\u308c\u308b\u305f\u3081\u3001\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u81ea\u4f53\u306f\u3001\u7814\u7a76\u4e0a\u304b\u306a\u308a\u4e00\u8cab\u3057\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3060\u304b\u3089\u3001GLP-1\u85ac\u3092\u4f7f\u3046\u306a\u3089\u5927\u5207\u306a\u306e\u306f\u3001\u300c\u3069\u3053\u307e\u3067\u75e9\u305b\u308b\u304b\u300d\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u85ac\u3092\u4f7f\u3063\u3066\u3044\u308b\u9593\u306b\u3001<\/p>\n<ul>\n<li>\u7dad\u6301\u3067\u304d\u308b\u98df\u4e8b\u91cf<\/li>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6<\/li>\n<li>\u7b4b\u30c8\u30ec\u30fb\u8eab\u4f53\u6d3b\u52d5<\/li>\n<li>\u85ac\u3092\u6e1b\u3089\u3059\u3001\u307e\u305f\u306f\u3084\u3081\u308b\u5834\u5408\u306e\u7dad\u6301\u30e9\u30a4\u30f3<\/li>\n<li>\u76ee\u6a19\u4f53\u91cd\u3067\u306f\u306a\u304f\u3001\u76ee\u6a19BMI<\/li>\n<\/ul>\n<p>\u307e\u3067\u8003\u3048\u3066\u304a\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"12_%E3%81%BE%E3%81%A8%E3%82%81\"><\/span>12. \u307e\u3068\u3081<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>BMJ\u7814\u7a76\u306f\u3001\u300c\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u308b\u3068\u4f53\u91cd\u304c\u623b\u308b\u300d\u3068\u3044\u3046\u91cd\u8981\u306a\u4e8b\u5b9f\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u305d\u308c\u3092\u305d\u306e\u307e\u307e\u300cGLP-1\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d\u3068\u8aad\u3080\u306b\u306f\u3001\u5c11\u3057\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>GLP-1\u85ac\u306f\u5927\u304d\u304f\u75e9\u305b\u3084\u3059\u3044\u85ac\u3067\u3059\u3002\u3060\u304b\u3089\u3001\u6700\u4f4e\u4f53\u91cd\u304b\u3089\u898b\u305f\u623b\u308a\u5e45\u3082\u5927\u304d\u304f\u306a\u308a\u3084\u3059\u3044\u3002<\/p>\n<p>\u300c\u4f55kg\u623b\u3063\u305f\u304b\u300d\u300c\u6e1b\u3063\u305f\u5206\u306e\u4f55\uff05\u304c\u623b\u3063\u305f\u304b\u300d\u3060\u3051\u3067\u306f\u3001\u8a55\u4fa1\u3068\u3057\u3066\u5341\u5206\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p>\u672c\u5f53\u306b\u898b\u305f\u3044\u306e\u306f\u3001<\/p>\n<ul>\n<li>\u958b\u59cbBMI<\/li>\n<li>\u6700\u4f4eBMI<\/li>\n<li>\u6700\u7d42BMI<\/li>\n<\/ul>\n<p>\u3067\u3059\u3002<\/p>\n<p>GLP-1\u85ac\u3067\u6df1\u304f\u4e0b\u304c\u3063\u305f\u4f53\u91cd\u304c\u3001\u85ac\u306a\u3057\u306e\u751f\u6d3b\u3067\u7dad\u6301\u3067\u304d\u308b\u6c34\u6e96\u307e\u3067\u623b\u3063\u305f\u3068\u3057\u3066\u3082\u3001\u305d\u308c\u3092\u305d\u306e\u307e\u307e\u300c\u30ea\u30d0\u30a6\u30f3\u30c9\u4f53\u8cea\u306b\u306a\u3063\u305f\u300d\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002<\/p>\n<p>\u3088\u308a\u6b63\u78ba\u306b\u306f\u3001<\/p>\n<blockquote><p>\nGLP-1\u85ac\u306f\u5927\u304d\u304f\u75e9\u305b\u3084\u3059\u3044\u3002<br \/>\n\u305f\u3060\u3057\u3001\u3084\u3081\u308b\u3068\u4f53\u91cd\u306f\u623b\u308a\u3084\u3059\u3044\u3002<br \/>\n\u305d\u306e\u623b\u308a\u3092\u8a55\u4fa1\u3059\u308b\u3068\u304d\u306f\u3001kg\u3060\u3051\u3067\u306f\u306a\u304fBMI\u306e\u6d41\u308c\u3067\u898b\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\n<\/p><\/blockquote>\n<p>\u3068\u3044\u3046\u8a71\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83%E6%96%87%E7%8C%AE\"><\/span>\u53c2\u8003\u6587\u732e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol>\n<li>West S, Scragg J, Aveyard P, Oke JL, Willis L, Haffner SJP, et al.<br \/>\nWeight regain after cessation of medication for weight management: systematic review and meta-analysis.<br \/>\nThe BMJ. 2026;392:e085304.<br \/>\ndoi:10.1136\/bmj-2025-085304<br \/>\n<a href=\"https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304\" target=\"_blank\" rel=\"noopener\">https:\/\/www.bmj.com\/content\/392\/bmj-2025-085304<\/a><\/li>\n<li>Wilding JPH, Batterham RL, Davies M, et al.<br \/>\nWeight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.<br \/>\nDiabetes, Obesity and Metabolism. 2022;24(8):1553\u20131564.<br \/>\ndoi:10.1111\/dom.14725<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35441470\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35441470\/<\/a><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9542252\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9542252\/<\/a><\/li>\n<li>Aronne LJ, Sattar N, Horn DB, et al.<br \/>\nContinued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial.<br \/>\nJAMA. 2024;331(1):38\u201348.<br \/>\ndoi:10.1001\/jama.2023.24945<br \/>\n<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2812936\" target=\"_blank\" rel=\"noopener\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2812936<\/a><\/li>\n<li>Horn DB, Linetzky B, Davies MJ, et al.<br \/>\nCardiometabolic Parameter Change by Weight Regain on Tirzepatide Withdrawal in Adults With Obesity: A Post Hoc Analysis of the SURMOUNT-4 Trial.<br \/>\nJAMA Internal Medicine. 2026;186(2):157\u2013167.<br \/>\ndoi:10.1001\/jamainternmed.2025.6112<br \/>\n<a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2841273\" target=\"_blank\" rel=\"noopener\">https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2841273<\/a><\/li>\n<li>Reuters.<br \/>\nLess than two years after stopping obesity drugs, weight and health issues return, study finds.<br \/>\nPublished January 7, 2026.<br \/>\n<a href=\"https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/less-than-two-years-after-stopping-obesity-drugs-weight-health-issues-return-2026-01-07\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/less-than-two-years-after-stopping-obesity-drugs-weight-health-issues-return-2026-01-07\/<\/a><\/li>\n<li>ClinicalTrials.gov.<br \/>\nSURMOUNT-4 Trial, NCT04660643.<br \/>\n<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04660643\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT04660643<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>TL;DR BMJ\u306b\u63b2\u8f09\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001GLP-1\u85ac\u306a\u3069\u306e\u6e1b\u91cf\u85ac\u3092\u3084\u3081\u308b\u3068\u3001\u4f53\u91cd\u304c\u623b\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u305d\u308c\u3092\u305d\u306e\u307e\u307e\u300cGLP-1\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u3057\u3084\u3059\u3044\u300d\u3068\u53d7\u3051\u53d6\u308b\u306b\u306f\u3001\u5c11\u3057\u614e\u91cd\u306a\u898b\u65b9\u304c\u5fc5\u8981\u3067\u3059\u3002 GL [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8],"tags":[],"class_list":["post-116","post","type-post","status-publish","format-standard","hentry","category-8"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/phgV64-1S","_links":{"self":[{"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/posts\/116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hanachan.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116"}],"version-history":[{"count":2,"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/posts\/116\/revisions"}],"predecessor-version":[{"id":118,"href":"https:\/\/hanachan.org\/index.php?rest_route=\/wp\/v2\/posts\/116\/revisions\/118"}],"wp:attachment":[{"href":"https:\/\/hanachan.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hanachan.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hanachan.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}